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New Painkiller That Combines Oxycodone and Naloxone Approved by FDA



A new painkiller that combines oxycodone and naloxone was approved by the U.S. Food and Drug Administration (FDA) on Wednesday. Naloxone was included in the drug to block the euphoric effects of oxycodone, making it less appealing to abuse.

The drug, Targiniq ER, is made by Purdue Pharma, which also makes OxyContin, the Los Angeles Times reports. Targiniq ER can be crushed and then snorted or injected. If the pills are crushed, the naloxone becomes active.

“Targiniq ER can still be abused, including when taken orally (by mouth), which is currently the most common way oxycodone is abused,” according to a statement by the FDA. Targiniq is expected to “deter, but not totally prevent” abuse, the FDA said.

“The FDA is committed to combating the misuse and abuse of all opioids,” Sharon Hertz, Deputy Director of the FDA’s Division of Anesthesia, Analgesia and Addiction Products, said in the statement. “The development of opioids that are harder to abuse is needed in order to help address the public health crisis of prescription drug abuse in the U.S.”

Dr. Andrew Kolodny, President of Physicians for Responsible Opioid Prescribing, told the newspaper he is concerned that doctors who believe Targiniq is safe may be more likely to prescribe it than to look for alternatives. “If we really want to turn this epidemic around, the most important thing is to stop creating new cases of addiction,” he said. “Coming up with new gimmicks isn’t going to help.”

Lynn Webster, a pain and addiction specialist and former president of the American Academy of Pain Medicine, said that while abuse-deterrent drugs such as Targiniq are not a good substitute for judicious prescribing, “the obvious alternative is not to have abuse-deterrent formulations, and I don’t know anyone who would find that preferable.”

4 Responses to this article

  1. Review / July 28, 2014 at 9:48 am

    I was on oxycontin, oxycodone for years due to the severe pain I’m in constantly. Not once was I addicted to it. In fact, I stopped taking it cold turkey because a new pain clinic doc asked me to. All that did was cause so much pain I wanted to die. I had to switch to morphine, and it doesn’t provide nearly the relief I had with the oxy. I have quit going anywhere and don’t even leave my house since then, due to the pain. It’s been at least 2 years now. Walmart won’t accept oxy as part of their plan, therefore I suffer more. Tell me that’s fair.

  2. Thea Bittinger / July 24, 2014 at 12:37 pm

    Finally this is ACTION IN THE MAKING….I am a recovering addict and I never injected any of my medications, but I did crushed them. This is the best thing I have heard in awhile for our addicts out there in awhile. There is so many availability out there for them today and they are so young and uneducated. It took me years to win with my own sobriety. I have a young adult time that just now owns his 64 days clean for the first time in 4 years. This is a great start….Keep praying…Blessings, Thea

  3. Lois Daunis / July 24, 2014 at 11:22 am

    Thank you, Dr. Kolodny. Your work with physicians is key to changing prescribing practices and patient risk assessment.

    • Paul Lyle / July 24, 2014 at 9:04 pm

      When will the drug be available for prescribing by doctors?
      Thank you.

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